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9FEJ

Structure of the RNA-dependent RNA polymerase P2 from the bacteriophage Phi8

Summary for 9FEJ
Entry DOI10.2210/pdb9fej/pdb
DescriptorRNA-directed RNA polymerase, CALCIUM ION (2 entities in total)
Functional Keywordspolymerase, viral protein
Biological sourcePseudomonas phage phi8
Total number of polymer chains1
Total formula weight71752.96
Authors
Latimer-Smith, M.,Salgado, P.S.,Forsyth, I.,Makeyev, E.,Poranen, M.,Stuart, D.I.,Grimes, J.M.,El Omari, K. (deposition date: 2024-05-20, release date: 2024-10-16, Last modification date: 2024-10-30)
Primary citationLatimer-Smith, M.,Salgado, P.S.,Forsyth, I.,Makeyev, E.,Poranen, M.M.,Stuart, D.I.,Grimes, J.M.,El Omari, K.
Structure of the RNA-dependent RNA polymerase P2 from the cystovirus phi 8.
Sci Rep, 14:23540-23540, 2024
Cited by
PubMed Abstract: The replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand. The P2 polymerase of cystovirus φ6 is currently among the best characterized viral RdRps. This polymerase is responsible for carrying out both replication and transcription of the viral double-stranded RNA genome using de novo initiation. Despite the extensive biochemical and structural studies conducted on φ6 P2, further structural information on other cystoviral RdRps is crucial to elucidate the structural and functional diversity of viral RdRps. Here, we have determined the atomic X-ray structure of the RdRp P2 from the φ6-related cystovirus φ8 at 3Å resolution. This structure completes the existing set of structural information on the φ8 polymerase complex and sheds light on the difference and similarities with related cystoviral RdRps.
PubMed: 39384884
DOI: 10.1038/s41598-024-75213-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

238895

数据于2025-07-16公开中

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