9F6K

Human DNA Polymerase epsilon bound to T-C mismatched DNA (Frayed Substrate state)

Summary for 9F6K

• Entry DOI: 10.2210/pdb9f6k/pdb
• EMDB information: 50227
• Descriptor: DNA polymerase epsilon catalytic subunit A, DNA nascent strand, DNA template strand, ... (4 entities in total)
• Functional Keywords: dna, polymerase, epsilon, pcna, leading strand, human, replication, replisome, proofreading
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 157538.47

Authors

Roske, J.J.,Yeeles, J.T.P. (deposition date: 2024-05-01, release date: 2024-08-07)

• Primary citation: Roske, J.J.,Yeeles, J.T.P.; Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.; Nat.Struct.Mol.Biol., 2024; DOI: 10.1038/s41594-024-01370-y

Experimental method

ELECTRON MICROSCOPY (4.2 Å)