9F5O

CryoEM structure of open sTeLIC in detergent, with 4-Bromoamphetamine

Summary for 9F5O

• Entry DOI: 10.2210/pdb9f5o/pdb
• EMDB information: 50195
• Descriptor: Cys-loop ligand-gated ion channel (1 entity in total)
• Functional Keywords: pentameric ligand-gated ion channel, cys-loop receptor, plgic, membrane protein
• Biological source: endosymbiont of Tevnia jerichonana (vent Tica)
• Total number of polymer chains: 5
• Total formula weight: 186554.10

Authors

Anden, O.,Howard, R.J.,Lindahl, E. (deposition date: 2024-04-29, release date: 2025-03-26, Last modification date: 2025-05-28)

Primary citation

Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.
Br.J.Pharmacol., 182:2790-2802, 2025

PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule.

PubMed: 40065647
DOI: 10.1111/bph.70011

Experimental method

ELECTRON MICROSCOPY (4.16 Å)