9F0A

N5 Adduct of LSD1-CoREST in complex with MC4455

Summary for 9F0A

Entry DOI	10.2210/pdb9f0a/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{S},3~{R},4~{S},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{S},3~{S},4~{R})-5-[5-[3-[4-[[4-[[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]carbamoyl]pyridin-2-yl]amino]phenyl]propanoyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4~{a}~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate (3 entities in total)
Functional Keywords	protein complex, epigenetics, inhibitor, flavoprotein, transcription, oxidoreductase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	102768.36
Authors	Barone, M.,Mattevi, A. (deposition date: 2024-04-15, release date: 2025-04-23)
Primary citation	Barone, M.,Mattevi, A. N5 Adduct of LSD1-CoREST in complex with MC4455 To Be Published,
Experimental method	X-RAY DIFFRACTION (3.36 Å)

Structure validation