9EWA

The sTeLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with 4-Bromophenethylamine

これはPDB形式変換不可エントリーです。

9EWA の概要

• エントリーDOI: 10.2210/pdb9ewa/pdb
• 分子名称: Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside, 2-(4-bromophenyl)ethanamine, ... (4 entities in total)
• 機能のキーワード: ion channel, membrane protein
• 由来する生物種: endosymbiont of Tevnia jerichonana (vent Tica)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 189086.46

構造登録者

Fourati, Z.,Delarue, M. (登録日: 2024-04-03, 公開日: 2025-03-26, 最終更新日: 2025-05-28)

主引用文献

Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.
Br.J.Pharmacol., 182:2790-2802, 2025

PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule.

PubMed: 40065647
DOI: 10.1111/bph.70011

実験手法

X-RAY DIFFRACTION (3.006 Å)