9EUU

Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo

Summary for 9EUU

• Entry DOI: 10.2210/pdb9euu/pdb
• EMDB information: 19986
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-synuclein, asyn, msa, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 18
• Total formula weight: 260569.94

Authors

Burger, D.,Kashyrina, M.,Lewis, A.,De Nuccio, F.,Mohammed, I.,de La Seigliere, H.,van den Heuvel, L.,Feuillie, C.,Verchere, J.,Berbon, M.,Arotcarena, M.,Retailleau, A.,Bezard, E.,Laferriere, F.,Loquet, A.,Bousset, L.,Baron, T.,Lofrumento, D.D.,De Giorgi, F.,Stahlberg, H.,Ichas, F. (deposition date: 2024-03-28, release date: 2024-06-05, Last modification date: 2025-06-18)

• Primary citation: Burger, D.,Kashyrina, M.,Lewis, A.J.,De Nuccio, F.,Mohammed, I.,de La Seigliere, H.,van den Heuvel, L.,Verchere, J.,Feuillie, C.,Berbon, M.,Arotcarena, M.L.,Retailleau, A.,Bezard, E.,Laferriere, F.,Loquet, A.,Bousset, L.,Baron, T.,Lofrumento, D.D.,De Giorgi, F.,Stahlberg, H.,Ichas, F.; 1.94 angstrom structure of synthetic alpha-synuclein fibrils seeding MSA neuropathology; Biorxiv, 2024; DOI: 10.1101/2024.07.01.601498

Experimental method

ELECTRON MICROSCOPY (1.93 Å)