Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9E6D

octopus sensory receptor CRT1 bound to Lumichrome

Summary for 9E6D
Entry DOI10.2210/pdb9e6d/pdb
EMDB information47556
DescriptorChemotactile receptor CRT1, 2-acetamido-2-deoxy-beta-D-glucopyranose, LUMICHROME (3 entities in total)
Functional Keywordscomplex, membrane protein
Biological sourceOctopus bimaculoides (California two-spot octopus)
Total number of polymer chains5
Total formula weight243412.68
Authors
Jiang, H.,Hibbs, R.E. (deposition date: 2024-10-29, release date: 2025-07-09)
Primary citationSepela, R.J.,Jiang, H.,Shin, Y.H.,Hautala, T.L.,Clardy, J.,Hibbs, R.E.,Bellono, N.W.
Environmental microbiomes drive chemotactile sensation in octopus.
Cell, 2025
Cited by
PubMed Abstract: Microbial communities coat nearly every surface in the environment and have co-existed with animals throughout evolution. Whether animals exploit omnipresent microbial cues to navigate their surroundings is not well understood. Octopuses use "taste-by-touch" chemotactile receptors (CRs) to explore the seafloor, but how they distinguish meaningful surfaces from the rocks and crevices they encounter is unknown. Here, we report that secreted signals from microbiomes of ecologically relevant surfaces activate CRs to guide octopus behavior. Distinct molecules isolated from individual bacterial strains located on prey or eggs bind single CRs in subtly different structural conformations to elicit specific mechanisms of receptor activation, ion permeation and signal transduction, and maternal care and predation behavior. Thus, microbiomes on ecological surfaces act at the level of primary sensory receptors to inform behavior. Our study demonstrates that uncovering interkingdom interactions is essential to understanding how animal sensory systems evolved in a microbe-rich world.
PubMed: 40532695
DOI: 10.1016/j.cell.2025.05.033
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.28 Å)
Structure validation

238582

数据于2025-07-09公开中

PDB statisticsPDBj update infoContact PDBjnumon