9DGE

Tetrahydroprotoberberine N-methyltransferase product complex with dextromethorphan and SAM

Summary for 9DGE

• Entry DOI: 10.2210/pdb9dge/pdb
• Related: 9DG6
• Descriptor: Tetrahydroprotoberberine N-methyltransferase, S-ADENOSYLMETHIONINE, Dextromethorphan, ... (5 entities in total)
• Functional Keywords: methyltransferase, benzylisoquinoline alkaloid, transferase
• Biological source: Glaucium flavum
• Total number of polymer chains: 1
• Total formula weight: 44567.82

Authors

Lang, D.E.,Ng, K.K.S. (deposition date: 2024-09-02, release date: 2025-09-17, Last modification date: 2025-11-19)

• Primary citation: Lang, D.E.,Ng, K.K.S.,Rehman, F.,Morris, J.S.,Facchini, P.J.; The stereospecific activities of the tetrahydroprotoberberine N-methyltransferase with alternative substrates provide insight into the catalytic mechanisms of benzylisoquinoline alkaloid N-methylation.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)