9DGB

Tetrahydroprotoberberine N-methyltransferase in complex with (S)-reticuline and SAM

Summary for 9DGB

• Entry DOI: 10.2210/pdb9dgb/pdb
• Related: 9DG6
• Descriptor: Tetrahydroprotoberberine N-methyltransferase, S-ADENOSYLMETHIONINE, (S)-reticuline, ... (5 entities in total)
• Functional Keywords: methyltransferase, benzylisoquinoline alkaloid, transferase
• Biological source: Glaucium flavum (Yellow horned-poppy)
• Total number of polymer chains: 1
• Total formula weight: 44621.85

Authors

Lang, D.E.,Ng, K.K.S. (deposition date: 2024-09-02, release date: 2025-09-17)

• Primary citation: Lang, D.E.,Ng, K.K.S.,Rehman, F.,Morris, J.S.,Facchini, P.J.; The stereospecific activities of the tetrahydroprotoberberine N-methyltransferase with alternative substrates provide insight into the catalytic mechanisms of benzylisoquinoline alkaloid N-methylation.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)