9D5Z

Crystal structure of the human WDR5 in complex with LH168 compound

This is a non-PDB format compatible entry.

Summary for 9D5Z

• Entry DOI: 10.2210/pdb9d5z/pdb
• Descriptor: WD repeat-containing protein 5, (3P)-N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5-[(1H-imidazol-1-yl)methyl]benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: wd-repeat, wdr, wdr5, sgc, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70059.43

Authors

Kimani, S.,Dong, A.,Hoffmann, L.,Nemec, V.,Ackloo, S.,Muller-Knapp, S.,Knapp, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2024-08-14, release date: 2025-02-19)

• Primary citation: Kimani, S.,Dong, A.,Hoffmann, L.,Nemec, V.,Ackloo, S.,Muller-Knapp, S.,Knapp, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Crystal structure of the human WDR5 in complex with LH168 compound; To be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)