9D5D

Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A

これはPDB形式変換不可エントリーです。

9D5D の概要

• エントリーDOI: 10.2210/pdb9d5d/pdb
• 分子名称: Factor VIIIa light chain (2 entities in total)
• 機能のキーワード: blood coagulation factor viii, lipid binding protein, factor viii c2 domain mutant, blood clotting
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18563.10

構造登録者

Avery, N.G.,Childers, K.C.,Spiegel, P.C. (登録日: 2024-08-13, 公開日: 2024-09-04, 最終更新日: 2024-12-18)

主引用文献

Avery, N.G.,Young, I.R.,Lu, S.,Vaughan, J.D.,Korus, P.S.,Richardson, T.N.,Childers, K.C.,Smirnov, S.L.,Spiegel Jr., P.C.
Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces.
J.Thromb.Haemost., 2024

PubMed Abstract: Following proteolytic activation, activated blood coagulation factor (F)VIII (FVIIIa) binds to activated platelet membranes, forming the intrinsic tenase complex with activated FIX (FIXa). Previous studies have identified the C1 and C2 domains as the membrane binding domains of FVIII through conserved arginine residues. A membrane binding model for the FVIII C domains proposes that surface-exposed hydrophobic and positively charged residues at each C domain interact with the membrane, yet a comprehensive thermodynamic and structural description of this interaction is lacking.

PubMed: 39549835
DOI: 10.1016/j.jtha.2024.11.003

実験手法

X-RAY DIFFRACTION (1.83 Å)