9D51

Structure of PAK2 in complex with compound 12

Summary for 9D51

Entry DOI	10.2210/pdb9d51/pdb
Descriptor	PAK-2p34, N~2~-{[(1s,4s)-4-aminocyclohexyl]methyl}-N~4~-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-2,4-diamine (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, transferase, inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	67263.87
Authors	Cakici, O.,Suto, R.K.,Olland, A.M. (deposition date: 2024-08-13, release date: 2025-04-02)
Primary citation	Johns, D.,Olejniczak, J.,Babbar, A.,Boone, C.,Cakici, O.,Cheng, M.,Cheng, Q.,Dementiev, A.,Eick, M.,Ferdyan, N.,Fontano, E.,Forman, A.,Goel, V.,Hirst, G.,Kozlowski, R.,Lee, S.,Mehta, S.,Mowery, K.,Murray, B.,Nguyen, V.,Olland, A.,Phan, K.,Reich, S.,Rivera, L.,Sabat, M.,Sprengeler, P.,Srinivasan, K.,Sun, Z.,Suto, R.,Wilkinson, T.,Wang, C.,Yu, N.,Xu, M. Identification of a p21-Activated Kinase 1 (PAK1) Inhibitor with 10-fold Selectivity Against PAK2 To Be Published,
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation