9CZL

Straight tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques

Summary for 9CZL

• Entry DOI: 10.2210/pdb9czl/pdb
• EMDB information: 46420
• Descriptor: Isoform Tau-C of Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: tau filaments, sf, cotton wool plaques, neurodegeneration, neuropeptide, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 80693.21

Authors

Hoq, M.R.,Vago, F.S.,Ozcan, K.A.,Bharath, S.R. (deposition date: 2024-08-05, release date: 2024-10-02)

• Primary citation: Hoq, M.R.,Fernandez, A.,Vago, F.S.,Hallinan, G.I.,Bharath, S.R.,Li, D.,Ozcan, K.A.,Garringer, H.J.,Jiang, W.,Vidal, R.,Ghetti, B.; Cryo-EM structures of cotton wool plaques' amyloid beta and of tau filaments in dominantly inherited Alzheimer disease.; Acta Neuropathol, 148:20-20, 2024; PubMed: 39147931; DOI: 10.1007/s00401-024-02786-y

Experimental method

ELECTRON MICROSCOPY (2.9 Å)