9CZL

Straight tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques

9CZL の概要

• エントリーDOI: 10.2210/pdb9czl/pdb
• EMDBエントリー: 46420
• 分子名称: Isoform Tau-C of Microtubule-associated protein tau (1 entity in total)
• 機能のキーワード: tau filaments, sf, cotton wool plaques, neurodegeneration, neuropeptide, protein fibril
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 80693.21

構造登録者

Hoq, M.R.,Vago, F.S.,Ozcan, K.A.,Bharath, S.R. (登録日: 2024-08-05, 公開日: 2024-10-02)

• 主引用文献: Hoq, M.R.,Fernandez, A.,Vago, F.S.,Hallinan, G.I.,Bharath, S.R.,Li, D.,Ozcan, K.A.,Garringer, H.J.,Jiang, W.,Vidal, R.,Ghetti, B.; Cryo-EM structures of cotton wool plaques' amyloid beta and of tau filaments in dominantly inherited Alzheimer disease.; Acta Neuropathol, 148:20-20, 2024; PubMed: 39147931; DOI: 10.1007/s00401-024-02786-y

実験手法

ELECTRON MICROSCOPY (2.9 Å)