9CPI
Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1
This is a non-PDB format compatible entry.
Summary for 9CPI
Entry DOI | 10.2210/pdb9cpi/pdb |
NMR Information | BMRB: 31190 |
Descriptor | RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3'), 4-[1-(2-aminoethyl)-4,5-dihydro-1H-imidazol-2-yl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzamide (2 entities in total) |
Functional Keywords | cug repeats, rna, myotonic dystrophy type 1, dm1, 5'cug/3'guc |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 8643.46 |
Authors | Chen, J.L.,Taghavi, A.,Disney, M.D.,Fountain, M.A.,Childs-Disney, J.L. (deposition date: 2024-07-18, release date: 2024-08-07, Last modification date: 2024-08-14) |
Primary citation | Chen, J.L.,Taghavi, A.,Frank, A.J.,Fountain, M.A.,Choudhary, S.,Roy, S.,Childs-Disney, J.L.,Disney, M.D. NMR structures of small molecules bound to a model of a CUG RNA repeat expansion. Bioorg.Med.Chem.Lett., 111:129888-129888, 2024 Cited by PubMed: 39002937DOI: 10.1016/j.bmcl.2024.129888 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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