9CLB

Crystal structure of Bak bound to the inhibitory aBAK

Summary for 9CLB

• Entry DOI: 10.2210/pdb9clb/pdb
• Descriptor: Bcl-2 homologous antagonist/killer, aBAK (2 entities in total)
• Functional Keywords: bak, inhibitor, bh3-mimetic, computational design, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 101523.04

Authors

Birkinshaw, R.W.,Berger, S.A.,Lee, E.F.,Harris, T.J.,Tran, S.,Bera, A.K.,Arguinchona, L.,Kang, A.,Sankaran, B.,Kasapgil, S.,Miller, M.S.,Smyth, S.,Uren, R.,Kluck, R.,Colman, P.M.,Fairlie, W.D.,Czabotar, P.E.,Baker, D. (deposition date: 2024-07-10, release date: 2025-07-16)

• Primary citation: Berger, S.A.,Lee, E.F.,Harris, T.J.,Tran, S.,Bera, A.K.,Arguinchona, L.,Kang, A.,Sankaran, B.,Kasapgil, S.,Miller, M.S.,Smyth, S.,Uren, R.,Kluck, R.,Colman, P.M.,Fairlie, W.D.,Czabotar, P.E.,Baker, D.,Birkinshaw, R.W.; Computational design of potent and selective inhibitors of BAK and BAX; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.86 Å)