9C5T

Cryo EM structure of DCAF2

Summary for 9C5T

Entry DOI	10.2210/pdb9c5t/pdb
EMDB information	45224
Descriptor	Denticleless protein homolog, DNA damage-binding protein 1 (2 entities in total)
Functional Keywords	dcaf2, e3 ligase, dtl, ddb1, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	178984.59
Authors	McMahon, E.J.,Wang, W. (deposition date: 2024-06-06, release date: 2025-10-01)
Primary citation	McMahon, E.J.,Cioffi, A.G.,Visperas, P.R.,Lin, Y.,Shaghafi, M.,Daczkowski, C.M.,Hermann, J.C.,Everley, R.A.,Neve, R.M.,Erlanson, D.A.,Webster, K.R.,Narayan, V.,Wang, W. Structural Basis for DCAF2 as a Novel E3 Ligase for PROTAC-Mediated Targeted Protein Degradation Structure, 2025
Experimental method	ELECTRON MICROSCOPY (3.36 Å)

Structure validation