9C55

Crystal structure of human PTPN2 in complex with active site inhibitor

Summary for 9C55

• Entry DOI: 10.2210/pdb9c55/pdb
• Related: 9C54
• Descriptor: Tyrosine-protein phosphatase non-receptor type 2, 5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: phosphatase, apo, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37325.13

Authors

Bester, S.M.,Linwood, R.,Wu, W.-I.,Mou, T.-C. (deposition date: 2024-06-05, release date: 2024-09-04)

• Primary citation: Bester, S.M.,Linwood, R.,Kataoka, R.,Wu, W.I.,Mou, T.C.; Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.; Acta Crystallogr.,Sect.F, 2024; PubMed: 39177701; DOI: 10.1107/S2053230X24007866

Experimental method

X-RAY DIFFRACTION (2.36 Å)