9C1V

M. tuberculosis PKS13 acyltransferase (AT) domain in complex with SuFEx inhibitor CMX410

This is a non-PDB format compatible entry.

Summary for 9C1V

• Entry DOI: 10.2210/pdb9c1v/pdb
• Related: 9C0P 9C1C 9C1D
• Related PRD ID: PRD_900003
• Descriptor: Polyketide synthase Pks13, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, PENTAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: polyketide synthase, acyltransferase, tuberculosis, inhibitor, structural genomics, tb structural genomics consortium, tbsgc, transferase, transferase-transferse inhibitor complex, transferase/transferse inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 2
• Total formula weight: 115452.74

Authors

Krieger, I.K.,Tang, S.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2024-05-29, release date: 2025-05-07)

• Primary citation: Krieger, I.K.,Sacchettini, J.C.,McNamara, C.W.; A SuFEx-based TB clinical candidate irreversibly inhibits Pks13; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.57 Å)