9BZN

High resolution structure of class A Beta-lactamase from Bordetella bronchiseptica RB50

9BZN の概要

• エントリーDOI: 10.2210/pdb9bzn/pdb
• 分子名称: class A Beta-lactamase, PenP superfamily, FORMIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: lactamase, serine hydrolase, penp, csbid, center for structural biology of infectious diseases, structural genomics, hydrolase
• 由来する生物種: Bordetella bronchiseptica RB50
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29056.55

構造登録者

Maltseva, N.,Kim, Y.,Endres, M.,Joachimiak, A.,Center for Structural Biology of Infectious Diseases (CSBID) (登録日: 2024-05-24, 公開日: 2024-06-12, 最終更新日: 2025-09-24)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (1.05 Å)