9BXQ
Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids
Summary for 9BXQ
Entry DOI | 10.2210/pdb9bxq/pdb |
EMDB information | 45008 |
Descriptor | Microtubule-associated protein tau (1 entity in total) |
Functional Keywords | amyloid, filament, neurodegeneration, down syndrome, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 50223.47 |
Authors | Tse, E.,Ghosh, U.,Condello, C.,Southworth, D. (deposition date: 2024-05-22, release date: 2024-08-14) |
Primary citation | Ghosh, U.,Tse, E.,Yang, H.,Shi, M.,Caro, C.D.,Wang, F.,Merz, G.E.,Prusiner, S.B.,Southworth, D.R.,Condello, C. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta Neuropathol Commun, 12:94-94, 2024 Cited by PubMed: 38867338DOI: 10.1186/s40478-024-01806-y PDB entries with the same primary citation |
Experimental method |
Structure validation
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