9BXQ

Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids

Summary for 9BXQ

• Entry DOI: 10.2210/pdb9bxq/pdb
• EMDB information: 45008
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: amyloid, filament, neurodegeneration, down syndrome, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 50223.47

Authors

Tse, E.,Ghosh, U.,Condello, C.,Southworth, D. (deposition date: 2024-05-22, release date: 2024-08-14)

• Primary citation: Ghosh, U.,Tse, E.,Yang, H.,Shi, M.,Caro, C.D.,Wang, F.,Merz, G.E.,Prusiner, S.B.,Southworth, D.R.,Condello, C.; Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.; Acta Neuropathol Commun, 12:94-94, 2024; PubMed: 38867338; DOI: 10.1186/s40478-024-01806-y

Experimental method