9BOO

Crystal structure of MERS-CoV Nsp5 in complex with PF-07817883

Summary for 9BOO

Entry DOI	10.2210/pdb9boo/pdb
Descriptor	3C-like proteinase nsp5, N-(methoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-(trifluoromethyl)-L-prolinamide (3 entities in total)
Functional Keywords	pf-07817883, nsp5, main protease, mers-cov, viral protein
Biological source	Middle East respiratory syndrome-related coronavirus
Total number of polymer chains	1
Total formula weight	33845.68
Authors	Chen, P.,Arutyunova, E.,Lemieux, M.J. (deposition date: 2024-05-05, release date: 2024-08-07, Last modification date: 2024-09-11)
Primary citation	Chen, P.,Van Oers, T.J.,Arutyunova, E.,Fischer, C.,Wang, C.,Lamer, T.,van Belkum, M.J.,Young, H.S.,Vederas, J.C.,Lemieux, M.J. A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M pro ) of SARS-CoV-2 and MERS-CoV. Jacs Au, 4:3217-3227, 2024 Cited by PubMed: 39211604 DOI: 10.1021/jacsau.4c00508 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation