9BC6

HCN1 M305L with propofol

Summary for 9BC6

• Entry DOI: 10.2210/pdb9bc6/pdb
• EMDB information: 42116 42117 44425
• Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL (3 entities in total)
• Functional Keywords: inhibitor, complex, membrane protein, nanodisc, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 305512.83

Authors

Kim, E.D.,Nimigean, C.M. (deposition date: 2024-04-07, release date: 2024-07-31)

• Primary citation: Kim, E.D.,Wu, X.,Lee, S.,Tibbs, G.R.,Cunningham, K.P.,Di Zanni, E.,Perez, M.E.,Goldstein, P.A.,Accardi, A.,Larsson, H.P.,Nimigean, C.M.; Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants; Nature, 2024; DOI: 10.1038/s41586-024-07743-z

Experimental method

ELECTRON MICROSCOPY (2.5 Å)