9BAE

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, and JK-5-115

This is a non-PDB format compatible entry.

Summary for 9BAE

• Entry DOI: 10.2210/pdb9bae/pdb
• Descriptor: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, 6-hydroxy-2-phenyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione, ... (5 entities in total)
• Functional Keywords: ketol-acid reductoisomerase, inhibitor, nadph, 2-acetolactate, isomerase
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 2
• Total formula weight: 74164.66

Authors

Kurz, J.L.,Lin, X.,Guddat, L.W. (deposition date: 2024-04-03, release date: 2025-04-09)

• Primary citation: Lin, X.,Kurz, J.L.; A ketol-acid reductoisomerase inhibitor that is competitive for both NADPH and 2-acetolactate exhibits both antituberculosis and herbicidal activity.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.73 Å)