9B6K

Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2

Summary for 9B6K

Entry DOI	10.2210/pdb9b6k/pdb
EMDB information	44262
Descriptor	Transient receptor potential cation channel subfamily M member 8, CALCIUM ION (2 entities in total)
Functional Keywords	trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	526353.56
Authors	Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (deposition date: 2024-03-25, release date: 2024-08-21)
Primary citation	Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y. Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10:eadp2211-eadp2211, 2024 Cited by PubMed: 39093967 DOI: 10.1126/sciadv.adp2211 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.13 Å)

Structure validation