9B6K
Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2
Summary for 9B6K
Entry DOI | 10.2210/pdb9b6k/pdb |
EMDB information | 44262 |
Descriptor | Transient receptor potential cation channel subfamily M member 8, CALCIUM ION (2 entities in total) |
Functional Keywords | trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 526353.56 |
Authors | Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (deposition date: 2024-03-25, release date: 2024-08-21) |
Primary citation | Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y. Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10:eadp2211-eadp2211, 2024 Cited by PubMed: 39093967DOI: 10.1126/sciadv.adp2211 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.13 Å) |
Structure validation
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