9B6G

Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB

Summary for 9B6G

Entry DOI	10.2210/pdb9b6g/pdb
EMDB information	44258
Descriptor	Transient receptor potential cation channel subfamily M member 8, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... (4 entities in total)
Functional Keywords	trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	538390.72
Authors	Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (deposition date: 2024-03-25, release date: 2024-08-21)
Primary citation	Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y. Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10:eadp2211-eadp2211, 2024 Cited by PubMed: 39093967 DOI: 10.1126/sciadv.adp2211 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation