9B6E

Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014

9B6E の概要

• エントリーDOI: 10.2210/pdb9b6e/pdb
• EMDBエントリー: 44256
• 分子名称: Transient receptor potential cation channel subfamily M member 8, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE (3 entities in total)
• 機能のキーワード: trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 535850.49

構造登録者

Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (登録日: 2024-03-25, 公開日: 2024-08-21)

• 主引用文献: Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y.; Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.; Sci Adv, 10:eadp2211-eadp2211, 2024; PubMed: 39093967; DOI: 10.1126/sciadv.adp2211

実験手法

ELECTRON MICROSCOPY (2.91 Å)