9AX6

Tricomplex of RMC-6236, KRAS G12D, and CypA

これはPDB形式変換不可エントリーです。

9AX6 の概要

• エントリーDOI: 10.2210/pdb9ax6/pdb
• 分子名称: GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: inhibitor, complex, small gtpase, cancer, tricomplex, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77751.78

構造登録者

Tomlinson, A.C.A.,Saldajeno-Concar, M.,Knox, J.E.,Yano, J.K. (登録日: 2024-03-05, 公開日: 2024-04-17)

• 主引用文献: Jiang, J.,Jiang, L.,Maldonato, B.J.,Wang, Y.,Holderfield, M.,Aronchik, I.,Winters, I.P.,Salman, Z.,Blaj, C.,Menard, M.,Brodbeck, J.,Chen, Z.,Wei, X.,Rosen, M.J.,Gindin, Y.,Lee, B.J.,Evans, J.W.,Chang, S.,Wang, Z.,Seamon, K.J.,Parsons, D.,Cregg, J.,Marquez, A.,Tomlinson, A.C.A.,Yano, J.K.,Knox, J.E.,Quintana, E.,Aguirre, A.J.,Arbour, K.C.,Reed, A.,Gustafson, W.C.,Gill, A.L.,Koltun, E.S.,Wildes, D.,Smith, J.A.M.,Wang, Z.,Singh, M.; Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.; Cancer Discov, :OF1-OF24, 2024; PubMed: 38593348; DOI: 10.1158/2159-8290.CD-24-0027

実験手法

X-RAY DIFFRACTION (1.65 Å)