9AT2

Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3 inhibitor

This is a non-PDB format compatible entry.

Summary for 9AT2

• Entry DOI: 10.2210/pdb9at2/pdb
• Related: 8W2K
• Descriptor: Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, alpha-methyl-L-tryptophan, ... (5 entities in total)
• Functional Keywords: inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 185454.81

Authors

Geeraerts, Z.,Yeh, S.-R. (deposition date: 2024-02-26, release date: 2024-08-28, Last modification date: 2024-09-11)

• Primary citation: Geeraerts, Z.,Ishigami, I.,Lewis-Ballester, A.,Pham, K.N.,Kozlova, A.,Mathieu, C.,Frederick, R.,Yeh, S.R.; Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.; J.Med.Chem., 67:14543-14552, 2024; PubMed: 39106326; DOI: 10.1021/acs.jmedchem.4c01360

Experimental method

X-RAY DIFFRACTION (2.25 Å)