8ZXQ

Crystal structure of Ssr1698 in complex with heme b

8ZXQ の概要

• エントリーDOI: 10.2210/pdb8zxq/pdb
• 分子名称: Ssr1698 protein, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: ssr1698, heme b, heme c, metal binding protein
• 由来する生物種: Synechocystis sp. (strain PCC 6803 / Kazusa)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12259.62

構造登録者

Wang, X.,Liu, L. (登録日: 2024-06-14, 公開日: 2024-12-25, 最終更新日: 2025-04-16)

主引用文献

Wang, X.Y.,Zhang, J.,Li, H.Y.,Dong, C.S.,Dai, H.E.,Wang, M.,Liu, L.
Structural Basis for Monomer-Dimer Transition of Dri1 Upon Heme Binding.
Proteins, 93:949-956, 2025

PubMed Abstract: Domain related to iron (DRI) contains approximately 90 residues and is involved in iron and heme metabolism. Recent discoveries have annotated Dri1, a DRI-only protein from the cyanobacterium Synechocystis, as a regulator of succinate dehydrogenase in a b-type heme-dependent manner or as a c-type heme oxygenase. Here, we report high-resolution structures of Dri1 in complex with b-type and c-type hemes, respectively. Bis-His-ligated heme is located in the middle of the dimeric Dri1 complex with heme b, as well as in the complex of monomeric Dri1 with c-type heme, but distinct heme binding modes are revealed. Structural analyses suggest that Dri1 may participate in the succinate dehydrogenase activity and/or the metabolism of cytochromes.

PubMed: 39670557
DOI: 10.1002/prot.26778

実験手法

X-RAY DIFFRACTION (1.51 Å)