8ZUD
Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8f
This is a non-PDB format compatible entry.
Summary for 8ZUD
Entry DOI | 10.2210/pdb8zud/pdb |
Descriptor | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 2-azanyl-3-(2,6-dimethyl-3-oxidanyl-phenyl)-5-(2-morpholin-4-ylpyridin-4-yl)benzamide (3 entities in total) |
Functional Keywords | protein kinase, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32129.57 |
Authors | Zhang, Z.M.,Zhou, Z.Q. (deposition date: 2024-06-08, release date: 2024-09-11, Last modification date: 2024-09-25) |
Primary citation | Wang, C.,Fang, Y.,Zhou, Z.,Liu, Z.,Feng, F.,Wan, X.,Li, Y.,Liu, S.,Ding, J.,Zhang, Z.M.,Xie, H.,Lu, X. Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. J.Med.Chem., 67:15816-15836, 2024 Cited by PubMed: 39163619DOI: 10.1021/acs.jmedchem.4c01458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5051008788 Å) |
Structure validation
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