8ZM2

Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16

これはPDB形式変換不可エントリーです。

8ZM2 の概要

• エントリーDOI: 10.2210/pdb8zm2/pdb
• 分子名称: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate (3 entities in total)
• 機能のキーワード: pdhk, kinase inhibitors, fragment screening, pdk1, pdk2, pdk3, pdk4, transferase-inhibitor complex, transferase/inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44955.98

構造登録者

Akai, S.,Orita, T.,Nomura, A.,Adachi, T. (登録日: 2024-05-22, 公開日: 2024-06-19, 最終更新日: 2024-07-03)

• 主引用文献: Inoue, M.,Nagamori, H.,Morita, T.,Kobayashi, S.,Suzawa, K.,Kitao, Y.,Saito, T.,Kawahara, I.,Orita, T.,Akai, S.,Adachi, T.,Motomura, T.; Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase.; Bioorg.Med.Chem.Lett., 109:129839-129839, 2024; PubMed: 38844173; DOI: 10.1016/j.bmcl.2024.129839

実験手法