8ZM1
Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 6
This is a non-PDB format compatible entry.
Summary for 8ZM1
Entry DOI | 10.2210/pdb8zm1/pdb |
Descriptor | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, (5~{R})-5-propan-2-ylindeno[1,2-b]pyridin-5-ol (3 entities in total) |
Functional Keywords | pdhk, kinase inhibitors, fragment screening, pdk1, pdk2, pdk3, pdk4, transferase-inhibitor complex, transferase/inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 44873.02 |
Authors | Akai, S.,Orita, T.,Nomura, A.,Adachi, T. (deposition date: 2024-05-22, release date: 2024-06-19, Last modification date: 2024-07-03) |
Primary citation | Inoue, M.,Nagamori, H.,Morita, T.,Kobayashi, S.,Suzawa, K.,Kitao, Y.,Saito, T.,Kawahara, I.,Orita, T.,Akai, S.,Adachi, T.,Motomura, T. Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109:129839-129839, 2024 Cited by PubMed: 38844173DOI: 10.1016/j.bmcl.2024.129839 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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