8ZHA
HIV-1 integrase core domain in complex with compound 15
This is a non-PDB format compatible entry.
Summary for 8ZHA
Entry DOI | 10.2210/pdb8zha/pdb |
Related | 8ZH4 |
Descriptor | Integrase, TETRAETHYLENE GLYCOL, (2~{S})-2-[7-(cycloheptylcarbamoyl)-4',5-dimethyl-spiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, ... (5 entities in total) |
Functional Keywords | hiv, integrase, inhibitor, viral protein |
Biological source | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) |
Total number of polymer chains | 1 |
Total formula weight | 19433.71 |
Authors | Furuzono, T.,Orita, T.,Nomura, A.,Adachi, T. (deposition date: 2024-05-10, release date: 2024-07-10, Last modification date: 2024-07-24) |
Primary citation | Adachi, K.,Manabe, T.,Yamasaki, T.,Suma, A.,Orita, T.,Furuzono, T.,Adachi, T.,Ohata, Y.,Akiyama, Y.,Miyazaki, S. Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 110:129864-129864, 2024 Cited by PubMed: 38942126DOI: 10.1016/j.bmcl.2024.129864 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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