8Z8M
Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab
Summary for 8Z8M
Entry DOI | 10.2210/pdb8z8m/pdb |
Descriptor | Tumor necrosis factor, TNF30:VHH (3 entities in total) |
Functional Keywords | tnf, vhh, ozoralizumab, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 186569.61 |
Authors | |
Primary citation | Mima, M.,Mishima-Tsumagari, C.,Nakano, K.,Morimoto, M.,Ogata, H.,Sakata, M.,Iwaoka, R.,Iwata, K.,Hachiuma, K.,Iwamoto, K.,Fujii, Y.,Kurokawa, T. Structural design of the anti-TNF alpha therapeutic NANOBODY® compound, ozoralizumab, to support its potent and sustained clinical efficacy. Biochem.Biophys.Res.Commun., 734:150454-150454, 2024 Cited by PubMed: 39083975DOI: 10.1016/j.bbrc.2024.150454 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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