8Z3A

Crystal structure of Sonic hedgehog in complex with antibody 5E1 without metals

8Z3A の概要

• エントリーDOI: 10.2210/pdb8z3a/pdb
• 分子名称: Sonic hedgehog protein N-product, Heavy chain of antibody 5E1, Light chain of antibody 5E1, ... (6 entities in total)
• 機能のキーワード: sonic hedgehog protein (shh), antibody, flexible/fluctuated epitope, affinity improvement, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71603.63

構造登録者

Caaveiro, J.M.M.,Kaneda, I.,Tsumoto, K. (登録日: 2024-04-15, 公開日: 2025-04-16)

• 主引用文献: Kaneda, I.,Matsunaga, R.,Nagatoishi, S.,Senoo, A.,Caaveiro, J.M.M.,Kuroda, D.,Tsumoto, K.; Biophysical insights to improve affinity of antibodies to fluctuated epitope of antigen: A case of anti-Shh antibody 5E1 against Shh antigen.; To Be Published,

実験手法

X-RAY DIFFRACTION (1.75 Å)