8YVG

canine immunoproteasome 20S subunit in complex with compound 1

This is a non-PDB format compatible entry.

Summary for 8YVG

• Entry DOI: 10.2210/pdb8yvg/pdb
• EMDB information: 39600
• Descriptor: Proteasome subunit alpha type, Proteasome subunit beta, [(2~{R},3~{S})-3-azanyl-4-oxidanylidene-butan-2-yl]oxy-[(1~{R})-1-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]-3-methyl-butyl]-$l^{3}-oxidanyl-oxidanyl-boron, ... (15 entities in total)
• Functional Keywords: inhibitor, complex, immunoproteasome, hydrolase
• Biological source: Canis lupus familiaris (dog); More
• Total number of polymer chains: 28
• Total formula weight: 741124.22

Authors

Kashima, A.,Arai, Y. (deposition date: 2024-03-28, release date: 2024-07-31)

• Primary citation: Arai, Y.,Shitama, H.,Yamagishi, M.,Ono, S.,Kashima, A.,Hiraizumi, M.,Tsuda, N.,Katayama, K.,Tanaka, K.,Koda, Y.,Kato, S.,Sakata, K.,Nureki, O.,Miyazaki, H.; Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor.; Bioorg.Med.Chem., 109:117790-117790, 2024; PubMed: 38906067; DOI: 10.1016/j.bmc.2024.117790

Experimental method

ELECTRON MICROSCOPY (2 Å)