8YMG

BRD4-BD1 in complex with 7-[4-chloro-1-(tetrahydropyran-4-ylmethyl)imidazol-2-yl]-5-methyl-2-{[(2R)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}furo[3,2-c]pyridin-4-one

これはPDB形式変換不可エントリーです。

8YMG の概要

• エントリーDOI: 10.2210/pdb8ymg/pdb
• 分子名称: Bromodomain-containing protein 4, 7-[4-chloro-1-(tetrahydropyran-4-ylmethyl)imidazol-2-yl]-5-methyl-2-{[(2R)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}furo[3,2-c]pyridin-4-one (3 entities in total)
• 機能のキーワード: brd4, epigenetic, signaling protein-inhibitor complex, signaling protein/inhibitor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15694.49

構造登録者

Sasaki, C.,Miyaguchi, I.,Hagihara, S.,Ishizawa, K.,Endo, J. (登録日: 2024-03-09, 公開日: 2025-03-12)

• 主引用文献: Hagihara, S.,Ishizawa, K.,Kikuchi, M.,Kawano, Y.,Nishidate, A.,Matsumoto, F.,Hashimoto, N.,Sasaki, C.,Miyaguchi, I.,Okada, O.,Akashi, T.,Nakayama, S.,Ogasawara, Y.,Endo, J.; Discovery of a potent, orally available furopyridine derivative as a novel selective BET BD1 Inhibitor (Part 1).; To Be Published,

実験手法

X-RAY DIFFRACTION (1.007 Å)