8YLC

The crystal structure of PDE4D with Amentoflavone

This is a non-PDB format compatible entry.

Summary for 8YLC

• Entry DOI: 10.2210/pdb8ylc/pdb
• Descriptor: 3',5'-cyclic-AMP phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 116773.15

Authors

Huang, Y.-Y.,Luo, H.-B. (deposition date: 2024-03-06, release date: 2024-06-12)

• Primary citation: Chen, Z.,Shi, Y.,Zhong, F.,Zhang, K.,Zhang, F.,Xie, S.,Cheng, Z.,Zhou, Q.,Huang, Y.Y.,Luo, H.B.; Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects; Chin.Chem.Lett., :109956-, 2024; DOI: 10.1016/j.cclet.2024.109956

Experimental method

X-RAY DIFFRACTION (2.30003722879 Å)