8YDK

Crystal structure of a novel design for RSV F protein in pre-fusion state

8YDK の概要

• エントリーDOI: 10.2210/pdb8ydk/pdb
• 分子名称: Fusion glycoprotein F2, F1 (2 entities in total)
• 機能のキーワード: respiratory syncytial virus, f protein, pre-fusion state, novel design, viral protein
• 由来する生物種: Human respiratory syncytial virus A
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 83093.61

構造登録者

Qi, J.X.,Li, J. (登録日: 2024-02-20, 公開日: 2025-08-20, 最終更新日: 2025-09-10)

主引用文献

Li, J.,Ma, X.,Xu, Z.,Guo, W.,Peng, R.,Zhang, Y.,Meng, Y.,Zhao, J.,Wang, Q.,Li, S.,Chen, J.,Guo, Y.,Lu, X.,Wang, Q.,Guo, Y.,Jia, M.A.,Li, Y.,Zhang, Y.,Li, S.,Du, P.,Wang, Q.,Gao, G.F.,Qi, J.
Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms.
Ebiomedicine, 119:105902-105902, 2025

PubMed Abstract: Respiratory syncytial virus (RSV) poses a significant public health threat, particularly to children and the elderly. Two protein-based vaccines and one mRNA vaccine have been approved, all targeting the prefusion conformation of the fusion (F) trimer. However, it has been reported that the epitope activity of the F protein gradually declines during storage, resulting in a reduction of the vaccines' immunogenicity.

PubMed: 40886405
DOI: 10.1016/j.ebiom.2025.105902

実験手法

X-RAY DIFFRACTION (2.1 Å)