8Y6L

Oryza sativa HKT1;5 salt sensitive variant

8Y6L の概要

• エントリーDOI: 10.2210/pdb8y6l/pdb
• EMDBエントリー: 38990
• 分子名称: Cation transporter HKT1;5,Soluble cytochrome b562 (1 entity in total)
• 機能のキーワード: dimer, transmembrane protein, sodium transporter, bril-fused, membrane protein
• 由来する生物種: Oryza sativa (Asian cultivated rice); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141803.61

構造登録者

Yang, G.H.,Gao, R. (登録日: 2024-02-02, 公開日: 2024-12-11)

主引用文献

Gao, R.,Jia, Y.,Xu, X.,Fu, P.,Zhou, J.,Yang, G.
Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance.
J Integr Plant Biol, 66:700-708, 2024

PubMed Abstract: The high-affinity potassium transporters (HKTs), selectively permeable to either Na alone or Na/K, play pivotal roles in maintaining plant Na/K homeostasis. Although their involvement in salt tolerance is widely reported, the molecular underpinnings of Oryza sativa HKTs remain elusive. In this study, we elucidate the structures of OsHKT1;1 and OsHKT2;1, representing two distinct classes of rice HKTs. The dimeric assembled OsHKTs can be structurally divided into four domains. At the dimer interface, a half-helix or a loop in the third domain is coordinated by the C-terminal region of the opposite subunit. Additionally, we present the structures of OsHKT1;5 salt-tolerant and salt-sensitive variants, a key quantitative trait locus associated with salt tolerance. The salt-tolerant variant of OsHKT1;5 exhibits enhanced Na transport capability and displays a more flexible conformation. These findings shed light on the molecular basis of rice HKTs and provide insights into their role in salt tolerance.

PubMed: 38409933
DOI: 10.1111/jipb.13632

実験手法

ELECTRON MICROSCOPY (3.4 Å)