8Y3W

The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (same side)

8Y3W の概要

• エントリーDOI: 10.2210/pdb8y3w/pdb
• EMDBエントリー: 38902
• 分子名称: SIR2-like domain-containing protein, DSR anti-defence 1 (2 entities in total)
• 機能のキーワード: nadase, anti-phage defense, complex, immune evasion, immunosuppressant
• 由来する生物種: Bacillus subtilis; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 502289.02

構造登録者

Wang, R.W.,Xu, Q.,Wu, Z.X.,Li, J.L.,Shi, Z.B.,Li, F.X. (登録日: 2024-01-29, 公開日: 2024-09-11)

• 主引用文献: Wang, R.,Xu, Q.,Wu, Z.,Li, J.,Guo, H.,Liao, T.,Shi, Y.,Yuan, L.,Gao, H.,Yang, R.,Shi, Z.,Li, F.; The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.; Nat Commun, 15:6185-6185, 2024; PubMed: 39039073; DOI: 10.1038/s41467-024-50410-0

実験手法

ELECTRON MICROSCOPY (3.49 Å)