8XX0

Crystal structure of anti-IgE antibody HMK-12 Fab complexed with IgE F(ab')2

Summary for 8XX0

• Entry DOI: 10.2210/pdb8xx0/pdb
• Descriptor: anti-IgE antibody HMK-12 Fab light chain, anti-IgE antibody HMK-12 Fab heavy chain, SPE7 immunoglobulin E F(ab')2 heavy chain, ... (8 entities in total)
• Functional Keywords: allergy, allosteric, immune system
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 4
• Total formula weight: 108240.82

Authors

Hirano, T.,Koyanagi, A.,Kasai, M.,Okumura, K. (deposition date: 2024-01-17, release date: 2024-07-31, Last modification date: 2024-08-07)

• Primary citation: Hirano, T.,Koyanagi, A.,Kasai, M.,Okumura, K.; Allosteric inhibition of the IgE-Fc epsilon RI interactions by targeting epitopes on IgE F(ab')2 regions; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)