8XT1

Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline

This is a non-PDB format compatible entry.

Summary for 8XT1

• Entry DOI: 10.2210/pdb8xt1/pdb
• EMDB information: 38633
• Descriptor: 16s rRNA, Large ribosomal subunit protein uL14m, Large ribosomal subunit protein uL15m, ... (55 entities in total)
• Functional Keywords: ribosome, tigecycline, antibiotic
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 52
• Total formula weight: 1743741.46

Authors

Li, X.,Wang, M.,Cheng, J. (deposition date: 2024-01-10, release date: 2024-07-10)

• Primary citation: Li, X.,Wang, M.,Denk, T.,Buschauer, R.,Li, Y.,Beckmann, R.,Cheng, J.; Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.; Nat Commun, 15:5481-5481, 2024; PubMed: 38942792; DOI: 10.1038/s41467-024-49797-7

Experimental method

ELECTRON MICROSCOPY (3.1 Å)