8XR9

Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus

8XR9 の概要

• エントリーDOI: 10.2210/pdb8xr9/pdb
• EMDBエントリー: 38599
• 分子名称: Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: h2n2, influenza virus, receptor, replication, transmission, mice, guinea pig, ferret, mutation, public health risk, virus, viral protein
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 173594.32

構造登録者

Sun, J.,Zheng, T.Y. (登録日: 2024-01-06, 公開日: 2025-01-15, 最終更新日: 2025-07-02)

主引用文献

Sun, J.,Zheng, T.,Jia, M.,Wang, Y.,Yang, J.,Liu, Y.,Yang, P.,Xie, Y.,Sun, H.,Tong, Q.,Li, J.,Yang, J.,Fu, G.,Shi, Y.,Qi, J.,Liu, W.,Liu, J.,Tian, W.X.,Gao, G.F.,Bi, Y.
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15:10012-10012, 2024

PubMed Abstract: The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype.

PubMed: 39562538
DOI: 10.1038/s41467-024-54374-z

実験手法

ELECTRON MICROSCOPY (2.6 Å)