8XK2

A neutralizing nanobody VHH60 against wt SARS-CoV-2

8XK2 の概要

• エントリーDOI: 10.2210/pdb8xk2/pdb
• 分子名称: Spike protein S1, VHH60 nanobody (2 entities in total)
• 機能のキーワード: covid-19, spike glycoprotein, virus, antibody, viral protein/immune system, viral protein-immune system complex, antiviral protein, antiviral protein-immune system complex, antiviral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 152402.68

構造登録者

Lu, Y.,Guo, H.,Ji, X.,Yang, H. (登録日: 2023-12-22, 公開日: 2024-07-10)

• 主引用文献: Liu, Q.,Lu, Y.,Cai, C.,Huang, Y.,Zhou, L.,Guan, Y.,Fu, S.,Lin, Y.,Yan, H.,Zhang, Z.,Li, X.,Yang, X.,Yang, H.,Guo, H.,Lan, K.,Chen, Y.,Hou, S.C.,Xiong, Y.; A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug.; Cell Death Dis, 15:458-458, 2024; PubMed: 38937437; DOI: 10.1038/s41419-024-06802-7

実験手法

X-RAY DIFFRACTION (3.4 Å)