8X71

Crystal structure of Peroxiredoxin I in complex with compound 19-064

8X71 の概要

• エントリーDOI: 10.2210/pdb8x71/pdb
• 分子名称: Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate (3 entities in total)
• 機能のキーワード: oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39831.61

構造登録者

Zhang, H.,Luo, C. (登録日: 2023-11-22, 公開日: 2024-06-19)

• 主引用文献: Wang, J.,Rong, Q.,Ye, L.,Fang, B.,Zhao, Y.,Sun, Y.,Zhou, H.,Wang, D.,He, J.,Cui, Z.,Zhang, Q.,Kang, D.,Hu, L.; Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.; J.Med.Chem., 67:7197-7223, 2024; PubMed: 38655686; DOI: 10.1021/acs.jmedchem.4c00051

実験手法

X-RAY DIFFRACTION (1.58 Å)