8WZQ

Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with CCF0058981

Summary for 8WZQ

Entry DOI	10.2210/pdb8wzq/pdb
Descriptor	3C-like proteinase nsp5, 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide (3 entities in total)
Functional Keywords	viral protein-inhibitor complex, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	2
Total formula weight	67936.27
Authors	Zou, X.F.,Jiang, H.H.,Zhou, X.L.,Zhang, J.,Li, J. (deposition date: 2023-11-02, release date: 2024-04-17)
Primary citation	Jiang, H.,Zou, X.,Zhou, X.,Zhang, J.,Li, J. Crystal structure of SARS-CoV-2 main protease (M pro ) mutants in complex with the non-covalent inhibitor CCF0058981. Biochem.Biophys.Res.Commun., 692:149352-149352, 2024 Cited by PubMed: 38056159 DOI: 10.1016/j.bbrc.2023.149352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation