8WZQ

Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with CCF0058981

8WZQ の概要

• エントリーDOI: 10.2210/pdb8wzq/pdb
• 分子名称: 3C-like proteinase nsp5, 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide (3 entities in total)
• 機能のキーワード: viral protein-inhibitor complex, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67936.27

構造登録者

Zou, X.F.,Jiang, H.H.,Zhou, X.L.,Zhang, J.,Li, J. (登録日: 2023-11-02, 公開日: 2024-04-17)

• 主引用文献: Jiang, H.,Zou, X.,Zhou, X.,Zhang, J.,Li, J.; Crystal structure of SARS-CoV-2 main protease (M pro ) mutants in complex with the non-covalent inhibitor CCF0058981.; Biochem.Biophys.Res.Commun., 692:149352-149352, 2024; PubMed: 38056159; DOI: 10.1016/j.bbrc.2023.149352

実験手法

X-RAY DIFFRACTION (1.66 Å)