8WZ0

SARS-CoV-2 3CLpro bound to covalent inhibitor

Summary for 8WZ0

• Entry DOI: 10.2210/pdb8wz0/pdb
• Descriptor: 3C-like proteinase nsp5, (2~{R})-~{N}-[4,4-bis(fluoranyl)cyclohexyl]-2-[(2-chloranyl-2-fluoranyl-ethanoyl)-[4-(trifluoromethyloxy)phenyl]amino]-2-pyrimidin-5-yl-propanamide (3 entities in total)
• Functional Keywords: protease inhibitor, covalent, virus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 68728.84

Authors

Peng, J.,Sun, D.,Ding, X. (deposition date: 2023-11-01, release date: 2025-05-07)

• Primary citation: Peng, J.,Sun, D.,Ding, X.; SARS-CoV-2 3CLpro bound to covalent inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)